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10.3791/53099 190 TolomanD.PanaO.StefanM.PopaA.LeosteanC.MacaveiS.et al (2019)

[29] Prespecified analyses suggest that cardiovascular benefit was not explained solely by baseline adiposity or achieved weight loss, supporting effects beyond simple weight reduction

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Activation of downstream effectors, including the mechanistic target of rapamycin complex 1 (mTORC1) and ribosomal protein S6 (S6), regulates protein synthesis, cell growth, and metabolism